# Platinum\-195 SDS \(Pt\-195 / 195Pt\) — Cisplatin, Enriched Cisplatin

Text extracted from the original PDF. Tables, images, symbols and OCR may differ. Check the original PDF for safety information.

- **Document title:** Platinum\-195 SDS \(Pt\-195 / 195Pt\) — Cisplatin, Enriched Cisplatin
- **Publisher:** Neonest AB
- **Material:** Cisplatin, Enriched Cisplatin
- **CAS number:** 15663\-27\-1
- **Product code / grade:** Enriched isotope · Platinum\-195 · Pt\-195 · 195Pt
- **Document type:** SDS
- **Original language:** English
- **Region:** Sweden
- **Revision date:** 21\-Oct\-2019
- **Page count:** 9
- **Original filename:** monoisotopic\-cisplatin\-195pt\-safety\-data\-sheet\-cisplatin\-195pt\-sds\.pdf
- **RESDS page:** https://resds\.com/document/cisplatin\-enriched\-cisplatin\-sds\-9ac9c49b59
- **Original PDF:** https://resds\.com/pdf/cisplatin\-enriched\-cisplatin\-sds\-9ac9c49b59\.pdf
- **Source URL:** https://www\.buyisotope\.com/sds/monoisotopic\-cisplatin\-195pt\-safety\-data\-sheet\-cisplatin\-195pt\-sds\.pdf
- **Description:** Safety Data Sheet for Cisplatin, Enriched Cisplatin, published by Neonest AB\. Supplier file designation: Platinum\-195 / Pt\-195 / 195Pt\.

## Page 1

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 1/9 
Section 1:   Identification of the Substance/Mixture and of the Company/Undertaking 
Product Identifier: 
Identification as on the label/Trade name:   Cisplatin, Enriched Cisplatin. 
Molecular weight:   300.05 
Chemical formula:   Pt(NH 3 ) 2 Cl 2 
Synonyms:   cis-Diammineplatinum(II) dichloride, Cisplatinum, cis-Dichlorodiammine platinum(II), cis-Platinum(II)
diammine dichloride. 
Details of the supplier of the Safety Data Sheet: 
Neonest AB 
Storgatan 70C, Solna 
SE-17152 
Sweden 
Contact details: 
+46-76-219-9731 
24-hour Emergency Contact: 
Swedish Poisons Centre 
Phone: 112 - Ask for Poisons Information, 112   –   begär Giftinformation . 
Other International Contacts: 
CHEMTREC 24-hour: +1-703-741-5500 (US + Worldwide) 
NHS: 111 (UK) 
Charite: +49 30 450 531 000 (Netherlands) 
INTCF: +34 917689800 (Spain) 
CapTv: +33 1 40 05 48 48 (France) 
Section 2: Hazards Identification 
Classification of the substances or mixture: 
The mixture is classified according to:   Regulation EC 1272/2008 [EU-GHS/CLP] 
Hazard classes/Hazard categories:   Hazard statement: 
Acute Toxicity (Category 2)   H300 
Eye Damage (Category 1)   H318 
Carcinogenic (Category 1B)   H350 
Label elements: 
Hazard pictograms:
```

## Page 2

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 2/9 
Signal Words:   Danger. 
Hazard Statements: 
H300 Fatal if swallowed. 
H318 Causes serious eye damage. 
H350 May cause cancer. 
Precautionary Statements: 
P201 Obtain special instructions before use. 
P202 Do not handle until all safety precautions have been read and understood. 
P264 Wash hands thoroughly after handling. 
P270 Do not eat, drink or smoke when using this product. 
P280 Wear protective gloves/protective clothing/eye protection/face protection. 
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. 
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing. 
P308 + P313 IF exposed or concerned: Get medical advice/attention. 
P310 Immediately call a POISON CENTER/doctor. 
P330 Rinse mouth. 
P405 Store locked up. 
P501 Dispose of contents/container in accordance with local/national regulations. 
Other hazards:   None known. 
Section 3: Composition/Information on Ingredients 
Substance/Mixture:   Substance. 
Ingredients: 
Substance name   (IUPAC/EC)   CAS - No.   Molecular 
weight 
Concentration 
% by weight 
Classification 
EC1272/2008 EC - No. 
Cisplatin 
15663-27-1 
300.05   >99% 
Acute Tox. 2   H300 
Eye Dam. 1   H318
Carc. 1B   H350 239-733-8 
For explanation of abbreviations see Section 16. 
Section 4: First - Aid Measures 
Description of first aid measures: 
Consult a physician. Show this safety data sheet to the doctor in attendance. 
If inhaled:   If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. 
In case of skin contact:   Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a
physician. 
In case of eye contact:   Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. 
If swallowed:   Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 
Most important symptoms and effects, both acute and delayed: 
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11. 
Indication of any immediate medical attention and special treatment needed:   Treat symptomatically. Show this
safety data sheet to a physician or emergency room.
```

## Page 3

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 3/9 
Section 5: Fire - Fighting Measures 
Extinguisher media: 
Suitable extinguisher media:   Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 
Unsuitable extinguishing media:   None known. 
Special hazards arising from the mixture:   Nitrogen oxides (NOx), Hydrogen chloride gas. 
Advice for fire-fighters:   Wear self-contained breathing apparatus for firefighting if necessary. 
Further information:   No data available. 
Section 6: Accidental Release Measures 
Personal precautions, protective equipment and emergency procedures: 
Personal precautions:   Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas.
Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. 
Environmental precautions:   Prevent further leakage or spillage if safe to do so. Do not let product enter drains. 
Methods for containment and cleaning up: 
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for
disposal. 
Reference to other sections: 
For disposal see section 13. 
Section 7: Handling and Storage 
Precautions for safe handling: 
Advice on safe handling:   Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure -
obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed. 
Hygiene measures:   Do not eat, drink or smoke when using this product. 
Conditions for safe storage, including incompatibilities: 
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage
temperature 2 -   8 °C. Storage class (TRGS 510): Combustible solids, toxic. 
Specific end use(s):   Apart from the uses mentioned in section 1.2 no other specific uses are stipulated. 
Section 8: Exposure Controls/ Personal Protection 
Control parameters: 
Occupational exposure limits:   No data available. 
Exposure controls: 
Appropriate engineering controls:   Avoid contact with skin, eyes and clothing. Wash hands before breaks and
immediately after handling the product. 
Individual protection measures, such as personal protective equipment: 
Eye/face protection:   Face shield and safety glasses Use equipment for eye protection tested and approved under
```

## Page 4

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 4/9 
appropriate government standards such as NIOSH (US) or EN 166(EU). 
Skin protection:   Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after
use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective
gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. 
Body Protection:   Complete suit protecting against chemicals, the type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace. 
Respiratory Protection:   Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator 
cartridges as a backup to engineering controls. If the full-face supplied air respirator. Use respirators and components
tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). 
Control of environmental exposure:   Prevent further leakage or spillage if safe to do so. Do not let product enter
drains. 
Section 9: Physical and Chemical Properties 
Information on basic physical and chemical properties 
Appearance (form):   Solid (powder). 
Colour:   Yellow. 
Odour:   No data available. 
Odour threshold:   No data available. 
Molecular Weight:   300.05 
pH (concentration):   No data available. 
Melting point/range (° C):   270 °C 
Boiling point/range (° C):   No data available. 
Freezing point   (°C):   No data available. 
Flash point (° C):   Not applicable. 
Evaporation rate:   No data available. 
Flammability (solid, gas):   No data available. 
Ignition temperature (° C):   No data available. 
Upper/lower flammability/explosive limits:   No data available. 
Vapour   pressure (20 ° C):   No data available. 
Vapour density:   No data available. 
Relative densi ty (25 ° C):   3.7 g/cm 3 
Water solubility (g/L ) at 20 ° C:   <0.1 g/100 mL 
n-Octanol/Water partition coefficient : No data available. 
Auto-ignition temperature:   No data available. 
Decomposition temperature:   No data available. 
Viscosity, dynamic (mPa s):   No data available. 
Explosive properties:   The substance or mixture is not classified as explosive. 
Oxidising properties:   The substance or mixture is not classified as oxidizing. 
Section 10: Stability and Reactivity 
Reactivity:   No data available. 
Chemical stability:   Stable under recommended storage conditions. 
Possibility of hazardous reactions:   No data available. 
Conditions to avoid:   No data available.
```

## Page 5

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 5/9 
Incompatible materials:   Strong oxidizing agents. 
Hazardous decomposition products:   Hazardous decomposition products formed under fire conditions: Nitrogen
oxides (NOx), Hydrogen chloride gas. 
Section 11: Toxicological Information 
Information on toxicological effects: 
Acute toxicity:   LD50 Oral - Rat - 25.8 mg/kg (Cisplatin) 
Classification according to GHS (1272/2008/EG, CLP) 
Skin corrosion/irritation: 
Not classified based on available information. 
Serious eye damage/eye irritation: 
Not classified based on available information. 
Respiratory or skin sensitisation: 
Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals. 
Germ cell mutagenicity: 
Not classified based on available information. 
Carcinogenicity: 
Possible human carcinogen.   IARC: 2A   -   Group 2A: Probably carcinogenic to humans 
Reproductive toxicity: 
Not classified based on available information. 
Specific target organ toxicity   –   single exposure (STOT): 
Not classified based on available information. 
Specific target organ toxicity (STOT)   –   repeated exposure: 
Not classified based on available information. 
Aspiration toxicity: 
Not classified based on available information. 
Section 12: Ecolo gical Information 
Toxicity:   No data available. 
Persistence and degradability:   No data available. 
Bioaccumulative potential:   No data available. 
Mobility in soil:   No data available. 
Results   of   PBT&   vPvB   assessment:   PBT/vPvB   assessment   not   available   as   chemical   safety   assessment   not
required/not conducted. 
Other adverse effects:   No data available. 
Section 13: Disposal Considerations 
Product:   Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with
a combustible solvent and burn in a chem scrubber. 
Contaminated packaging:   Dispose of as unused product. 
Section 14: Transport Information
```

## Page 6

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 6/9 
ADR/RID: 
Proper Shipping Name:   TOXIC SOLID, INORGANIC, N.O.S. (Cisplatin). 
Hazard Class : 6.1 
Hazard Label: 
UN Number:   3288 
Packing Group:   II 
IATA: 
Proper Shipping Name:   TOXIC SOLID, INORGANIC, N.O.S. (Cisplatin). 
Hazard Class : 6.1 
UN Number:   3288 
Packing Group:   II 
IMDG: 
Proper Shipping Name:   TOXIC SOLID, INORGANIC, N.O.S. (Cisplatin). 
Hazard Class : 6.1 
UN Number:   3288 
Packing Group:   II 
Section 15: Regulatory Information 
EU regulations: 
Regulation (EC) No. 1005/2009 on substances that deplete the ozone layer, Annex I and II, as amended 
Not listed. 
Regulation (EC) No. 850/2004 on persistent organic pollutants, Annex I 
Not listed. 
Regulation (EU) No. 649/2012 concerning the export and import of dangerous chemicals, Annex I, Part 1 as
amended 
Not listed. 
Regulation (EU) No. 649/2012 concerning the export and import of dangerous chemicals, Annex I, Part 2 as
amended 
Not listed. 
Regulation (EU) No. 649/2012 concerning the export and import of dangerous chemicals, Annex I, Part 3 as
amended 
Not listed. 
Regulation (EU) No. 649/2012 concerning the export and import of dangerous chemicals, Annex V as amended 
Not listed. 
Regulation (EC) No. 166/2006 Annex II Pollutant Release and Transfer Registry 
Not listed. 
Regulation (EC) No. 1907/2006, REACH Article 59(10) Candidate List as currently published by ECHA 
Not listed.
```

## Page 7

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 7/9 
Authorisations: 
Regulation (EC) No. 1907/2006, REACH Annex XIV Substances subject to authorization, as amended 
Not listed. 
Restrictions on use: 
Regulation (EC) No. 1907/2006 Annex XVII Substances subject to restriction on marketing and use 
Not regulated. 
Regulation (EC) No. 1907/2006, REACH Annex XVII Substances subject to restriction on marketing and use as
amended 
Not listed. 
Directive 2004/37/EC on the protection of workers from the risks related to exposure to carcinogens and mutagens
at work 
Not regulated. 
Directive 92/85/EEC: on the safety and health of pregnant workers and workers who have recently given birth or
are breastfeeding. 
Not regulated. 
Other EU regulations: 
Directive 2012/18/EU on major accident hazards involving dangerous substances 
Not listed. 
Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents
at work. 
Always applicable. 
Directive 94/33/EC on the protection of young people at work 
Not listed. 
Other regulations:   The product is classified and labelled in accordance with EC directives or respective national laws.
This Safety Data Sheet complies with the requirements of Regulation (EC) No 1907/2006, as amended. 
Chemical safety assessment:   No Chemical Safety Assessment has been carried out. 
Section 16: Other   Information 
List of abbreviations: 
ACGIH American Conference of Governmental Industrial Hygienists 
ADR European Agreement Concerning the International Carriage of Dangerous Goods by Road 
ALARA As Low As Is Reasonably Achievable 
AMU Atomic Mass Unit 
ANSI American National Standards Institute 
BLS Basic Life Support 
CAM Continuous Air Monitor 
CAS Chemical Abstracts Service (division of the American Chemical Society) 
CEN European Committee for Standardization 
CERCLA Comprehensive Environmental Response Compensation and Liability Act 
CLP Classification, Labelling and Packaging (European Union) 
CPR Controlled Products Regulations (Canada) 
CWA Clean Water Act (USA) 
DAC Derived Air Concentration (USA)
```

## Page 8

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 8/9 
DOE United States Department of Energy (USA) 
DOT United States Department of Transportation (USA) 
DSL Domestic Substances List (Canada) 
EC50 Half Maximal Effective Concentration 
EINECS European Inventory of Existing Commercial Chemical Substances 
EHS Environmentally Hazardous Substance 
ELINCS European List of Notified Chemical Substances 
EMS Emergency Response Procedures for Ships Carrying Dangerous Goods 
EPA Environmental Protection Agency (USA) 
EPCRA Emergency Planning and Community Right-To-Know Act (EPCRA) of 1986 
GHS Globally Harmonized System 
HMIS Hazardous Materials Identification System (USA) 
IARC International Agency for Research on Cancer 
IATA International Air Transport Association 
IBC Intermediate Bulk Containers 
ICAO International Civil Aviation Organization 
IDLH Immediately Dangerous to Life or Health 
IMDG International Maritime Code for Dangerous Goods 
LC50 Lethal concentration, 50 percent 
LD50 Lethal dose, 50 percent 
LDLO Lethal Dose Low 
LOEC Lowest-Observed-Effective Concentration 
MARPOL International Convention for the Prevention of Pollution from Ships 
MSHA Mine Safety and Health Administration (USA) 
NCRP National Council on Radiation Protection & Measurements (USA) 
NDSL Non-Domestic Substances List (Canada) 
NFPA National Fire Protection Association (USA) 
NIOSH National Institute for Occupational Safety and Health (USA) 
NOEC No Observed Effect Concentration 
N.O.S. Not Otherwise Specified 
NRC Nuclear Regulatory Commission (USA) 
NTP National Toxicology Program (USA) 
OSHA Occupational Safety and Health Administration (USA) 
PBT Persistent Bioaccumulative and Toxic Chemical 
PEL Permissible Exposure Limit 
PIH Poisonous by Inhalation Hazard 
RCRA Resource Conservation and Recovery Act (USA) 
RCT Radiation Control Technician 
REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (Europe) 
RID Regulations Concerning the International Transport of Dangerous Goods by Rail 
RTECS Registry of Toxic Effects of Chemical Substances 
SARA Superfund Amendments and Reauthorization Act (USA) 
TDG Transportation of Dangerous Goods (Canada) 
TIH Toxic by Inhalation Hazard 
TLV Threshold Limit Value 
TPQ Threshold Planning Quantity 
TSCA Toxic Substances Control Act 
TWA Time Weighted Average
```

## Page 9

```text
Safety Data Sheet for Cisplatin, Enriched Cisplatin 
According to ISO 11014:2010
First Print Date: 5-Mar-2015
Revision Date: 21-Oct-2019
Version: 1.1.1. 
Safety Data Sheet (SDS) for Cisplatin, Enriched Cisplatin   https://www.buyisotope.com   Page 9/9 
UN United Nations (Number) 
VOC Volatile Organic Compound 
vPvB Very Persistent Very Bioaccumulative Chemical 
WGK Wassergefährdungskl assen (Germany: Water Hazard Classes) 
WHMIS Workplace Hazardous Materials Information System 
References: 
Not available. 
Full text of any H-statements not written out in full under Sections 2 to 15: 
H300 Fatal if swallowed. 
H318 Causes serious eye damage. 
H350 May cause cancer. 
Revision information: 
None. 
Training information: 
Follow training instructions when handling this material. 
Further Information: 
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at
the date of its publication. The information given is designed only as a guidance for safe handling, use, processing,
storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The
information relates only to the specific material designated and may not be valid for such material used in
combination with any other materials or in any process, unless specified in the text.
```