Gadodiamide, European Pharmacopoeia (EP) Reference Standard SDS

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET Version 5.0 Revision Date 11/07/2017 Print Date 11/08/2018

1. PRODUCT AND COMPANY IDENTIFICATION

1.1 Product identifiers

Product name : Gadodiamide, European Pharmacopoeia (EP) Reference Standard

Product Number : Y0001875 Brand : Sigma-Aldrich

CAS-No. : 131410-48-5

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Synthesis of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA

Telephone : +1 800-325-5832 Fax : +1 800-325-5052

1.4 Emergency telephone number

Emergency Phone # : +1-703-527-3887 (CHEMTREC)

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture

Not a hazardous substance or mixture.

2.2 GHS Label elements, including precautionary statements

Not a hazardous substance or mixture.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances Formula : C16H26GdN5O8 CAS-No. : 131410-48-5

No components need to be disclosed according to the applicable regulations.

4. FIRST AID MEASURES

4.1 Description of first aid measures

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration.

Sigma-Aldrich - Y0001875 Page 1 of 7

In case of skin contact Wash off with soap and plenty of water.

In case of eye contact Flush eyes with water as a precaution.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

5. FIREFIGHTING MEASURES

5.1 Extinguishing media

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture No data available

5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures Avoid dust formation. Avoid breathing vapours, mist or gas. For personal protection see section 8.

6.2 Environmental precautions No special environmental precautions required.

6.3 Methods and materials for containment and cleaning up Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

7. HANDLING AND STORAGE

7.1 Precautions for safe handling Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Keep container tightly closed in a dry and well-ventilated place.

Recommended storage temperature 2 - 8 °C Storage class (TRGS 510): 13: Non Combustible Solids

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters

Components with workplace control parameters Contains no substances with occupational exposure limit values.

Sigma-Aldrich - Y0001875 Page 2 of 7

8.2 Exposure controls

Appropriate engineering controls General industrial hygiene practice.

Personal protective equipment

Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Body Protection Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure No special environmental precautions required.

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

a) Appearance Form: Crystalline powder Colour: white

b) Odour odourless

c) Odour Threshold No data available

d) pH 5.5 - 7

e) Melting point/freezing Melting point/range: 308 °C (586 °F) - Decomposes on heating. point

f) Initial boiling point and No data available boiling range

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available

j) Upper/lower No data available flammability or explosive limits

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density No data available

n) Water solubility soluble

o) Partition coefficient: n- No data available octanol/water

p) Auto-ignition No data available temperature

q) Decomposition No data available temperature

Sigma-Aldrich - Y0001875 Page 3 of 7

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Solubility in other Methanol - soluble solvents Ethanol - soluble Acetone - slightly soluble Chloroform - slightly soluble

10. STABILITY AND REACTIVITY

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available

10.5 Incompatible materials Oxidizing agents, Ammonia

10.6 Hazardous decomposition products

Other decomposition products - No data available Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), gadolinium oxides In the event of fire: see section 5

11. TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects

Acute toxicity LD50 Oral - Mouse - 19.7 g/kg

Inhalation: No data available

Dermal: No data available

No data available

Skin corrosion/irritation No data available

Serious eye damage/eye irritation Eyes - Rabbit Result: irritating Remarks: (External MSDS)

Respiratory or skin sensitisation - Guinea pig Result: negative Remarks: (External MSDS)

Germ cell mutagenicity No data available

Chromosome aberration test in vitro Chinese hamster ovary cells Result: negative (External MSDS)

Sigma-Aldrich - Y0001875 Page 4 of 7

Mouse Result: negative (External MSDS)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.

Reproductive toxicity No data available

No data available

Specific target organ toxicity - single exposure No data available

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available

Additional Information RTECS: Not available

12. ECOLOGICAL INFORMATION

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available

12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Other adverse effects

No data available

13. DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

14. TRANSPORT INFORMATION

DOT (US) Not dangerous goods

IMDG Not dangerous goods

Sigma-Aldrich - Y0001875 Page 5 of 7

IATA Not dangerous goods

15. REGULATORY INFORMATION

SARA 302 Components No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.

SARA 313 Components This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

SARA 311/312 Hazards No SARA Hazards

Massachusetts Right To Know Components No components are subject to the Massachusetts Right to Know Act.

Pennsylvania Right To Know Components CAS-No. Revision Date [5,8-Bis(carboxymethyl)-11-[2-(methylamino)-2-oxoethyl]-3- 131410-48-5 oxo-2,5,8,11-tetraazatridecan-13-oato (3-)]gadolinium

CAS-No. Revision Date [5,8-Bis(carboxymethyl)-11-[2-(methylamino)-2-oxoethyl]-3- 131410-48-5 oxo-2,5,8,11-tetraazatridecan-13-oato (3-)]gadolinium

New Jersey Right To Know Components CAS-No. Revision Date [5,8-Bis(carboxymethyl)-11-[2-(methylamino)-2-oxoethyl]-3- 131410-48-5 oxo-2,5,8,11-tetraazatridecan-13-oato (3-)]gadolinium

California Prop. 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

16. OTHER INFORMATION

HMIS Rating Health hazard: 0 Chronic Health Hazard: Flammability: 0 Physical Hazard 0

NFPA Rating Health hazard: 0 Fire Hazard: 0 Reactivity Hazard: 0

Further information Copyright 2016 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Sigma-Aldrich - Y0001875 Page 6 of 7

Preparation Information Sigma-Aldrich Corporation Product Safety – Americas Region 1-800-521-8956

Version: 5.0 Revision Date: 11/07/2017 Print Date: 11/08/2018

Sigma-Aldrich - Y0001875 Page 7 of 7