Gadolinium(III) chloride hexahydrate, REacton® | SDS | CAS 13450-84-5 | Alfa-Aesar | English | 09/19/2017 · Version 1

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Safety Data Sheet Page 1/4 acc. to OSHA HCS Printing date 09/20/2017 Revision date 09/19/2017 Version 1

1 Identification

Product identifier Product name: Gadolinium(III) chloride hexahydrate, REacton®

Stock number: 11286 CAS Number: 13450-84-5 EC number: 233-386-6 Relevant identified uses of the substance or mixture and uses advised against. Identified use: SU24 Scientific research and development Details of the supplier of the safety data sheet Manufacturer/Supplier: Alfa Aesar Thermo Fisher Scientific Chemicals, Inc. 30 Bond Street Ward Hill, MA 01835-8099 Tel: 800-343-0660 Fax: 800-322-4757 Email: tech@alfa.com www.alfa.com Information Department: Health, Safety and Environmental Department Emergency telephone number: During normal business hours (Monday-Friday, 8am-7pm EST), call (800) 343-0660. After normal business hours, call Carechem 24 at (866) 928-0789.

2 Hazard(s) identification

Classification of the substance or mixture in accordance with 29 CFR 1910 (OSHA HCS)

GHS07

Skin Irrit. 2 H315 Causes skin irritation. Eye Irrit. 2A H319 Causes serious eye irritation. Hazards not otherwise classified No information known. Label elements GHS label elements The product is classified and labeled in accordance with 29 CFR 1910 (OSHA HCS) Hazard pictograms

GHS07

Signal word Warning Hazard statements H315 Causes skin irritation. H319 Causes serious eye irritation. Precautionary statements P280 Wear protective gloves / eye protection / face protection. P264 Wash thoroughly after handling. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P321 Specific treatment (see on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. WHMIS classification D2B - Toxic material causing other toxic effects

Classification system HMIS ratings (scale 0-4) (Hazardous Materials Identification System) HEALTH 1 Health (acute effects) = 1 FIRE 0 Flammability = 0 REACTIVITY 0 Physical Hazard = 0 Other hazards Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable.

3 Composition/information on ingredients

Chemical characterization: Substances CAS# Description: 13450-84-5 Gadolinium(III) chloride hexahydrate Concentration: ื100% Identification number(s): EC number: 233-386-6

4 First-aid measures

Description of first aid measures After inhalation Supply fresh air. If required, provide artificial respiration. Keep patient warm. Seek immediate medical advice. After skin contact Immediately wash with water and soap and rinse thoroughly. (Contd. on page 2) USA

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Product name: Gadolinium(III) chloride hexahydrate, REacton®

(Contd. of page 1) Seek immediate medical advice. After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor. After swallowing Seek medical treatment. Information for doctor Most important symptoms and effects, both acute and delayed Causes skin irritation. Causes serious eye irritation. Indication of any immediate medical attention and special treatment needed No further relevant information available.

5 Fire-fighting measures

Extinguishing media Suitable extinguishing agents Product is not flammable. Use fire-fighting measures that suit the surrounding fire. Special hazards arising from the substance or mixture If this product is involved in a fire, the following can be released: Hydrogen chloride (HCl) Gadolinium oxide Advice for firefighters Protective equipment: Wear self-contained respirator. Wear fully protective impervious suit.

6 Accidental release measures

Personal precautions, protective equipment and emergency procedures Wear protective equipment. Keep unprotected persons away. Ensure adequate ventilation Environmental precautions: Do not allow product to reach sewage system or any water course. Methods and material for containment and cleaning up: Pick up mechanically. Prevention of secondary hazards: No special measures required. Reference to other sections See Section 7 for information on safe handling See Section 8 for information on personal protection equipment. See Section 13 for disposal information. Protective Action Criteria for Chemicals PAC-1: 2.2 mg/m3 PAC-2: 24 mg/m3 PAC-3: 140 mg/m3

7 Handling and storage

Handling Precautions for safe handling Handle under dry protective gas. Keep container tightly sealed. Store in cool, dry place in tightly closed containers. Ensure good ventilation at the workplace. Information about protection against explosions and fires: The product is not flammable Conditions for safe storage, including any incompatibilities Storage Requirements to be met by storerooms and receptacles: No special requirements. Information about storage in one common storage facility: Store away from water/moisture. Do not store together with acids. Store away from strong bases. Store away from oxidizing agents. Further information about storage conditions: Store under dry inert gas. This product is hygroscopic. Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Protect from humidity and water. Specific end use(s) No further relevant information available.

8 Exposure controls/personal protection

Additional information about design of technical systems: Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 feet per minute. Control parameters Components with limit values that require monitoring at the workplace: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace. Additional information: No data Exposure controls Personal protective equipment General protective and hygienic measures The usual precautionary measures for handling chemicals should be followed. Keep away from foodstuffs, beverages and feed. Remove all soiled and contaminated clothing immediately. Wash hands before breaks and at the end of work. Avoid contact with the eyes and skin. Maintain an ergonomically appropriate working environment. Breathing equipment: Use suitable respirator when high concentrations are present. Use suitable respiratory protective device in case of insufficient ventilation. Recommended filter device for short term use: Use a respirator with type N95 (USA) or PE (EN 143) cartridges as a backup to engineering controls. Risk assessment should be performed to determine if air- purifying respirators are appropriate. Only use equipment tested and approved under appropriate government standards. Protection of hands: Impervious gloves Check protective gloves prior to each use for their proper condition. The selection of suitable gloves not only depends on the material, but also on quality. Quality will vary from manufacturer to manufacturer. Eye protection: Safety glasses with side shields / NIOSH (US) or EN 166(EU) (Contd. on page 3) USA

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Product name: Gadolinium(III) chloride hexahydrate, REacton®

(Contd. of page 2) Body protection: Protective work clothing.

9 Physical and chemical properties

Information on basic physical and chemical properties General Information Appearance: Form: Crystalline aggregrates Odor: Not determined Odor threshold: Not determined. pH-value: Not applicable. Change in condition Melting point/Melting range: Not determined Boiling point/Boiling range: Not determined Sublimation temperature / start: Not determined Flammability (solid, gaseous) Not determined. Ignition temperature: Not determined Decomposition temperature: Not determined Auto igniting: Not determined. Danger of explosion: Not determined. Explosion limits: Lower: Not determined Upper: Not determined Vapor pressure: Not applicable. Density at 20 °C (68 °F): 2.424 g/cm³ (20.228 lbs/gal) Relative density Not determined. Vapor density Not applicable. Evaporation rate Not applicable. Solubility in / Miscibility with Water: Soluble Partition coefficient (n-octanol/water): Not determined. Viscosity: dynamic: Not applicable. kinematic: Not applicable. Other information No further relevant information available.

10 Stability and reactivity

Reactivity No information known. Chemical stability Stable under recommended storage conditions. Thermal decomposition / conditions to be avoided: Decomposition will not occur if used and stored according to specifications. Possibility of hazardous reactions Reacts with strong oxidizing agents Conditions to avoid No further relevant information available. Incompatible materials: Acids Bases Oxidizing agents Water/moisture Hazardous decomposition products: Hydrogen chloride (HCl) Gadolinium oxide

11 Toxicological information

Information on toxicological effects Acute toxicity: The Registry of Toxic Effects of Chemical Substances (RTECS) contains acute toxicity data for this substance. LD/LC50 values that are relevant for classification: No data Skin irritation or corrosion: Causes skin irritation. Eye irritation or corrosion: Causes serious eye irritation. Sensitization: No sensitizing effects known. Germ cell mutagenicity: No effects known. Carcinogenicity: No classification data on carcinogenic properties of this material is available from the EPA, IARC, NTP, OSHA or ACGIH. Reproductive toxicity: No effects known. Specific target organ system toxicity - repeated exposure: No effects known. Specific target organ system toxicity - single exposure: No effects known. Aspiration hazard: No effects known. Subacute to chronic toxicity: The Registry of Toxic Effects of Chemical Substances (RTECS) contains multiple dose toxicity data for this substance. Additional toxicological information: To the best of our knowledge the acute and chronic toxicity of this substance is not fully known.

12 Ecological information

Toxicity Aquatic toxicity: No further relevant information available. Persistence and degradability No further relevant information available. Bioaccumulative potential No further relevant information available. Mobility in soil No further relevant information available. Additional ecological information: General notes: Avoid transfer into the environment. Results of PBT and vPvB assessment PBT: Not applicable. vPvB: Not applicable. Other adverse effects No further relevant information available.

13 Disposal considerations

Waste treatment methods Recommendation Consult state, local or national regulations to ensure proper disposal. (Contd. on page 4) USA

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Product name: Gadolinium(III) chloride hexahydrate, REacton®

(Contd. of page 3) Uncleaned packagings: Recommendation: Disposal must be made according to official regulations. Recommended cleansing agent: Water, if necessary with cleansing agents.

14 Transport information

UN-Number DOT, ADN, IMDG, IATA Not applicable UN proper shipping name DOT, ADR, ADN, IMDG, IATA Not applicable Transport hazard class(es) DOT, ADR, ADN, IMDG, IATA Class Not applicable Packing group DOT, ADR, IMDG, IATA Not applicable Environmental hazards: Not applicable. Special precautions for user Not applicable. Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code Not applicable. Transport/Additional information: DOT Marine Pollutant (DOT): No UN "Model Regulation": Not applicable

15 Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture GHS label elements The product is classified and labeled in accordance with 29 CFR 1910 (OSHA HCS) Hazard pictograms

GHS07

Signal word Warning Hazard statements H315 Causes skin irritation. H319 Causes serious eye irritation. Precautionary statements P280 Wear protective gloves / eye protection / face protection. P264 Wash thoroughly after handling. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P321 Specific treatment (see on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P337+P313 If eye irritation persists: Get medical advice/attention. National regulations All components of this product are listed in the U.S. Environmental Protection Agency Toxic Substances Control Act Chemical substance Inventory. All components of this product are listed on the Canadian Domestic Substances List (DSL). SARA Section 313 (specific toxic chemical listings) Substance is not listed. California Proposition 65 Prop 65 - Chemicals known to cause cancer Substance is not listed. Prop 65 - Developmental toxicity Substance is not listed. Prop 65 - Developmental toxicity, female Substance is not listed. Prop 65 - Developmental toxicity, male Substance is not listed. Information about limitation of use: For use only by technically qualified individuals. Other regulations, limitations and prohibitive regulations Substance of Very High Concern (SVHC) according to the REACH Regulations (EC) No. 1907/2006. Substance is not listed. The conditions of restrictions according to Article 67 and Annex XVII of the Regulation (EC) No 1907/2006 (REACH) for the manufacturing, placing on the market and use must be observed. Substance is not listed. Annex XIV of the REACH Regulations (requiring Authorisation for use) Substance is not listed. Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

16 Other information

Employers should use this information only as a supplement to other information gathered by them, and should make independent judgement of suitability of this information to ensure proper use and protect the health and safety of employees. This information is furnished without warranty, and any use of the product not in conformance with this Safety Data Sheet, or in combination with any other product or process, is the responsibility of the user. Department issuing SDS: Global Marketing Department Date of preparation/Revision: Print date, revision date and version number are in the header of each page. Abbreviations and acronyms: ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the International Carriage of Dangerous Goods by Road) IMDG: International Maritime Code for Dangerous Goods DOT: US Department of Transportation IATA: International Air Transport Association EINECS: European Inventory of Existing Commercial Chemical Substances CAS: Chemical Abstracts Service (division of the American Chemical Society) HMIS: Hazardous Materials Identification System (USA) WHMIS: Workplace Hazardous Materials Information System (Canada) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent PBT: Persistent, Bioaccumulative and Toxic SVHC: Substances of Very High Concern vPvB: very Persistent and very Bioaccumulative ACGIH: American Conference of Governmental Industrial Hygienists (USA) OSHA: Occupational Safety and Health Administration (USA) NTP: National Toxicology Program (USA) IARC: International Agency for Research on Cancer EPA: Environmental Protection Agency (USA) Skin Irrit. 2: Skin corrosion/irritation – Category 2 Eye Irrit. 2A: Serious eye damage/eye irritation – Category 2A USA

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Gadolinium(III) chloride hexahydrate, REacton® | SDS | CAS 13450-84-5 | Alfa-Aesar | English | 09/19/2017 · Version 1

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Full document text

Page 1

1 Identification

2 Hazard(s) identification

3 Composition/information on ingredients

4 First-aid measures

Page 2

5 Fire-fighting measures

6 Accidental release measures

7 Handling and storage

8 Exposure controls/personal protection

Page 3

9 Physical and chemical properties

10 Stability and reactivity

11 Toxicological information

12 Ecological information

13 Disposal considerations

Page 4

14 Transport information

15 Regulatory information

16 Other information