Gadolinium(III) nitrate hexahydrate SDS

SAFETY DATA SHEET

Creation Date 22-Sep-2009 Revision Date 28-Aug-2015 Revision Number 3

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING

1.1. Product identification

Product Description: Gadolinium(III) nitrate hexahydrate Cat No. : 316760000; 316760250 Synonyms Nitric Acid, Gadolinium(3+) Salt, Hexahydrate. CAS-No 19598-90-4 Molecular Formula Gd N3 O9 . 6 H2 O

1.2. Relevant identified uses of the substance or mixture and uses advised against

Recommended Use Laboratory chemicals. Uses advised against No Information available

1.3. Details of the supplier of the safety data sheet

Company Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium E-mail address begel.sdsdesk@thermofisher.com

1.4. Emergency telephone number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99 CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887

SECTION 2: HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture

CLP Classification - Regulation (EC) No 1272/2008

Physical hazards

Oxidizing solids Category 2

Health hazards

Serious Eye Damage/Eye Irritation Category 1

Environmental hazards Based on available data, the classification criteria are not met

2.2. Label elements

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SAFETY DATA SHEET Gadolinium(III) nitrate hexahydrate Revision Date 28-Aug-2015 ______________________________________________________________________________________________

Signal Word Danger

Hazard Statements H272 - May intensify fire; oxidizer H318 - Causes serious eye damage

Precautionary Statements P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P310 - Immediately call a POISON CENTER or doctor/ physician P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection P210 - Keep away from heat/sparks/open flames/hot surfaces. - No smoking P221 - Take any precaution to avoid mixing with combustibles P371 + P380 + P375 - In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion

2.3. Other hazards

No information available

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1. Substances

Component CAS-No EC-No. Weight % CLP Classification - Regulation (EC) No 1272/2008 Gadolinium (III) nitrate, hexahydrate 19598-90-4 99.9 Eye Dam. 1 (H318) Ox. Sol. 2 (H272)

Full text of Hazard Statements: see section 16

SECTION 4: FIRST AID MEASURES

4.1. Description of first aid measures

General Advice If symptoms persist, call a physician.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain medical attention.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention.

Ingestion Clean mouth with water and drink afterwards plenty of water. Get medical attention if symptoms occur.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Obtain medical attention.

Protection of First-aiders Use personal protective equipment.

4.2. Most important symptoms and effects, both acute and delayed

None reasonably foreseeable. Causes eye burns.

4.3. Indication of any immediate medical attention and special treatment needed

Notes to Physician Treat symptomatically.

SECTION 5: FIREFIGHTING MEASURES

5.1. Extinguishing media ______________________________________________________________________________________________ ACR31676 Page 2 / 9

SAFETY DATA SHEET Gadolinium(III) nitrate hexahydrate Revision Date 28-Aug-2015 ______________________________________________________________________________________________

Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Extinguishing media which must not be used for safety reasons No information available.

5.2. Special hazards arising from the substance or mixture

Burning produces obnoxious and toxic fumes. Oxidizer: Contact with combustible/organic material may cause fire. May ignite combustibles (wood paper, oil, clothing, etc.).

Hazardous Combustion Products Nitrogen oxides (NOx).

5.3. Advice for firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Ensure adequate ventilation. Avoid dust formation.

6.2. Environmental precautions

Should not be released into the environment.

6.3. Methods and material for containment and cleaning up

Sweep up or vacuum up spillage and collect in suitable container for disposal. Keep in suitable, closed containers for disposal. Soak up with inert absorbent material. Sweep up and shovel into suitable containers for disposal.

6.4. Reference to other sections

Refer to protective measures listed in Sections 8 and 13.

SECTION 7: HANDLING AND STORAGE

7.1. Precautions for safe handling

Wear personal protective equipment. Ensure adequate ventilation. Do not get in eyes, on skin, or on clothing. Avoid ingestion and inhalation. Avoid dust formation. Keep away from clothing and other combustible materials.

7.2. Conditions for safe storage, including any incompatibilities

Keep containers tightly closed in a dry, cool and well-ventilated place. Do not store near combustible materials.

7.3. Specific end use(s)

Use in laboratories

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1. Control parameters

Exposure limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies

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SAFETY DATA SHEET Gadolinium(III) nitrate hexahydrate Revision Date 28-Aug-2015 ______________________________________________________________________________________________

Biological limit values This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific regulatory bodies.

Monitoring methods BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS14/3 General methods for sampling and gravimetric analysis of respirable and inhalable dust

Derived No Effect Level (DNEL) No information available Route of exposure Acute effects (local) Acute effects Chronic effects Chronic effects (systemic) (local) (systemic) Oral Dermal Inhalation

Predicted No Effect Concentration No information available. (PNEC)

8.2. Exposure controls

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source Personal protective equipment Eye Protection Goggles (European standard - EN 166) Hand Protection Protective gloves

Glove material Breakthrough time Glove thickness EU standard Glove comments Natural rubber See manufacturers - EN 374 (minimum requirement) Nitrile rubber recommendations Neoprene PVC Skin and body protection Long sleeved clothing

Inspect gloves before use. Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. (Refer to manufacturer/supplier for information) Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g. sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion. Remove gloves with care avoiding skin contamination.

Respiratory Protection When workers are facing concentrations above the exposure limit they must use appropriate certified respirators. To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly Large scale/emergency use Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits ______________________________________________________________________________________________ ACR31676 Page 4 / 9

SAFETY DATA SHEET Gadolinium(III) nitrate hexahydrate Revision Date 28-Aug-2015 ______________________________________________________________________________________________ are exceeded or if irritation or other symptoms are experienced Recommended Filter type: Particulates filter conforming to EN 143 Small scale/Laboratory use Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Recommended half mask:- Particle filtering: EN149:2001 When RPE is used a face piece Fit Test should be conducted

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

Environmental exposure controls No information available.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Appearance White Physical State Solid

Odor No information available Odor Threshold No data available pH No information available Melting Point/Range No data available Softening Point No data available Boiling Point/Range No information available Flash Point No information available Method - No information available Evaporation Rate Not applicable Solid Flammability (solid,gas) No information available Explosion Limits No data available

Vapor Pressure No data available Vapor Density Not applicable Solid Specific Gravity / Density No data available Bulk Density No data available Water Solubility soluble Solubility in other solvents No information available Partition Coefficient (n-octanol/water) Autoignition Temperature Decomposition Temperature No data available Viscosity Not applicable Solid Explosive Properties No information available Oxidizing Properties Oxidizer

9.2. Other information

Molecular Formula Gd N3 O9 . 6 H2 O Molecular Weight 451.4

SECTION 10: STABILITY AND REACTIVITY

10.1. Reactivity Yes

10.2. Chemical stability Stable under normal conditions: Oxidizer: Contact with combustible/organic material may cause fire 10.3. Possibility of hazardous reactions

Hazardous Polymerization Hazardous polymerization does not occur. Hazardous Reactions None under normal processing.

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SAFETY DATA SHEET Gadolinium(III) nitrate hexahydrate Revision Date 28-Aug-2015 ______________________________________________________________________________________________ 10.4. Conditions to avoid Incompatible products. Excess heat. Avoid dust formation. Combustible material. 10.5. Incompatible materials Strong acids. Strong reducing agents. Metals. Powdered metals. Combustible material.

10.6. Hazardous decomposition products

Nitrogen oxides (NOx).

SECTION 11: TOXICOLOGICAL INFORMATION

11.1. Information on toxicological effects

Product Information No acute toxicity information is available for this product

(a) acute toxicity; Oral Based on available data, the classification criteria are not met Dermal No data available Inhalation No data available

Component LD50 Oral LD50 Dermal LC50 Inhalation Gadolinium (III) nitrate, hexahydrate LD50 > 5 g/kg ( Rat )

(b) skin corrosion/irritation; No data available

(c) serious eye damage/irritation; Category 1

(d) respiratory or skin sensitization; Respiratory No data available Skin No data available

(e) germ cell mutagenicity; No data available

(f) carcinogenicity; No data available There are no known carcinogenic chemicals in this product

(g) reproductive toxicity; No data available

(h) STOT-single exposure; No data available

(i) STOT-repeated exposure; No data available

Target Organs No information available.

(j) aspiration hazard; Not applicable Solid

Other Adverse Effects The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information

Symptoms / effects,both acute and No information available delayed

SECTION 12: ECOLOGICAL INFORMATION

12.1. Toxicity Ecotoxicity effects Contains no substances known to be hazardous to the environment or that are not degradable in waste water treatment plants.

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SAFETY DATA SHEET Gadolinium(III) nitrate hexahydrate Revision Date 28-Aug-2015 ______________________________________________________________________________________________

12.2. Persistence and degradability Persistence Soluble in water, Persistence is unlikely, based on information available. Degradability Not relevant for inorganic substances.

12.3. Bioaccumulative potential Bioaccumulation is unlikely

12.4. Mobility in soil The product is water soluble, and may spread in water systems Will likely be mobile in the environment due to its water solubility. Highly mobile in soils

12.5. Results of PBT and vPvB No data available for assessment. assessment

12.6. Other adverse effects

Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors Persistent Organic Pollutant This product does not contain any known or suspected substance Ozone Depletion Potential This product does not contain any known or suspected substance

SECTION 13: DISPOSAL CONSIDERATIONS

13.1. Waste treatment methods

Waste from Residues / Unused Waste is classified as hazardous. Dispose of in accordance with the European Directives Products on waste and hazardous waste. Dispose of in accordance with local regulations.

Contaminated Packaging Dispose of this container to hazardous or special waste collection point.

European Waste Catalogue (EWC) According to the European Waste Catalogue, Waste Codes are not product specific, but application specific. Other Information Waste codes should be assigned by the user based on the application for which the product was used. Do not empty into drains. Do not dispose of waste into sewer.

SECTION 14: TRANSPORT INFORMATION

IMDG/IMO

14.1. UN number UN1477 14.2. UN proper shipping name NITRATES, INORGANIC, N.O.S

14.3. Transport hazard class(es) 5.1

14.4. Packing group III

ADR

14.1. UN number UN1477 14.2. UN proper shipping name NITRATES, INORGANIC, N.O.S

14.3. Transport hazard class(es) 5.1

14.4. Packing group III

IATA

14.1. UN number UN1477 14.2. UN proper shipping name NITRATES, INORGANIC, N.O.S

14.3. Transport hazard class(es) 5.1

14.4. Packing group III

14.5. Environmental hazards No hazards identified

14.6. Special precautions for user No special precautions required

14.7. Transport in bulk according to Not applicable, packaged goods

Annex II of MARPOL73/78 and the IBC Code ______________________________________________________________________________________________ ACR31676 Page 7 / 9

SAFETY DATA SHEET Gadolinium(III) nitrate hexahydrate Revision Date 28-Aug-2015 ______________________________________________________________________________________________

SECTION 15: REGULATORY INFORMATION

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

International Inventories X = listed The product is classified and labeled according to EC directives or corresponding national laws The product is classified and labeled in accordance with Directive 1999/45/EC

National Regulations

Take note of Control of Substances Hazardous to Health Regulations (COSHH) 2002 and 2005 Amendment. Take note of Dir 94/33/EC on the protection of young people at work Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at work

15.2. Chemical safety assessment

A Chemical Safety Assessment/Report (CSA/CSR) has not been conducted

SECTION 16: OTHER INFORMATION

Full Text of H-/EUH-Statements Referred to Under Section 3 H272 - May intensify fire; oxidizer H318 - Causes serious eye damage Legend

CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b) Inventory EINECS/ELINCS - European Inventory of Existing Commercial Chemical DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances/EU List of Notified Chemical Substances Substances List PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals

WEL - Workplace Exposure Limit TWA - Time Weighted Average ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer DNEL - Derived No Effect Level PNEC - Predicted No Effect Concentration RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50% LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50% NOEC - No Observed Effect Concentration POW - Partition coefficient Octanol:Water PBT - Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative

ADR - European Agreement Concerning the International Carriage of ICAO/IATA - International Civil Aviation Organization/International Air Dangerous Goods by Road Transport Association IMO/IMDG - International Maritime Organization/International Maritime MARPOL - International Convention for the Prevention of Pollution from Dangerous Goods Code Ships OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate BCF - Bioconcentration factor VOC - Volatile Organic Compounds Key literature references and sources for data Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS

Training Advice Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene. Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards. First aid for chemical exposure, including the use of eye wash and safety showers.

Creation Date 22-Sep-2009 Revision Date 28-Aug-2015 Revision Summary Update to Format. ______________________________________________________________________________________________ ACR31676 Page 8 / 9

SAFETY DATA SHEET Gadolinium(III) nitrate hexahydrate Revision Date 28-Aug-2015 ______________________________________________________________________________________________ This safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006

Disclaimer The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text. End of Safety Data Sheet

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