Gadolinium (III) sulfate SDS

SAFETY DATA SHEET according to Regulation UK SI 2019/758 and UK SI 2020/1577 as amended

Revision Date 02-Feb-2024 Revision Number 3

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING

1.1. Product identifier

Product Description: Gadolinium (III) sulfate Cat No. : 42869 CAS No 13450-87-8 Molecular Formula Gd2 O12 S3 . 8 H2 O REACH registration number -

1.2. Relevant identified uses of the substance or mixture and uses advised against

Recommended Use Laboratory chemicals. Uses advised against No Information available

1.3. Details of the supplier of the safety data sheet

Company . Avocado Research Chemicals Ltd. (Part of Thermo Fisher Scientific) Shore Road, Heysham Lancashire, LA3 2XY, United Kingdom Office Tel: +44 (0) 1524 850506 Office Fax: +44 (0) 1524 850608

E-mail address begel.sdsdesk@thermofisher.com

1.4. Emergency telephone number For information US call: 001-800-227-6701 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99 CHEMTREC Tel. No. US:001-800-424-9300 / Europe:001-703-527-3887

SECTION 2: HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture

CLP Classification - According to GB-CLP Regulations UK SI 2019/720 and UK SI 2020/1567

Physical hazards

Based on available data, the classification criteria are not met

Health hazards

Skin Corrosion/Irritation Category 2 (H315)

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SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________ Serious Eye Damage/Eye Irritation Category 2 (H319) Specific target organ toxicity - (single exposure) Category 3 (H335)

Environmental hazards Based on available data, the classification criteria are not met

Full text of Hazard Statements: see section 16

2.2. Label elements

Signal Word Warning

Hazard Statements H315 - Causes skin irritation H319 - Causes serious eye irritation H335 - May cause respiratory irritation

Precautionary Statements P261 - Avoid breathing dust/fume/gas/mist/vapors/spray P280 - Wear protective gloves/protective clothing/eye protection/face protection P302 + P352 - IF ON SKIN: Wash with plenty of soap and water P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing

2.3. Other hazards

This product does not contain any known or suspected endocrine disruptors

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1. Substances

Component CAS No EC No Weight % CLP Classification - According to GB-CLP Regulations UK SI 2019/720 and UK SI 2020/1567 Gadolinium(III) sulfate octahydrate 13450-87-8 99.9 Eye irrit. 2 (H319) STOT SE3 (H335) Skin Irrit. 2 (H315)

REACH registration number -

Full text of Hazard Statements: see section 16

SECTION 4: FIRST AID MEASURES

SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________ 4.1. Description of first aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention.

Skin Contact Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Get medical attention.

Ingestion Clean mouth with water. Get medical attention.

Inhalation Remove from exposure, lie down. Remove to fresh air. If not breathing, give artificial respiration. Get medical attention.

Self-Protection of the First Aider Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.

4.2. Most important symptoms and effects, both acute and delayed

No information available.

4.3. Indication of any immediate medical attention and special treatment needed

Notes to Physician Treat symptomatically.

SECTION 5: FIREFIGHTING MEASURES

5.1. Extinguishing media

Suitable Extinguishing Media Substance is nonflammable; use agent most appropriate to extinguish surrounding fire.

Extinguishing media which must not be used for safety reasons No information available.

5.2. Special hazards arising from the substance or mixture

Non-combustible.

Hazardous Combustion Products Sulfur oxides.

5.3. Advice for firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

Ensure adequate ventilation.

6.2. Environmental precautions

See Section 12 for additional Ecological Information.

6.3. Methods and material for containment and cleaning up

Sweep up and shovel into suitable containers for disposal. Do not let this chemical enter the environment.

6.4. Reference to other sections

SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________

Refer to protective measures listed in Sections 8 and 13.

SECTION 7: HANDLING AND STORAGE

7.1. Precautions for safe handling

Avoid contact with skin and eyes. Do not breathe dust. Do not ingest. If swallowed then seek immediate medical assistance.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do not eat, drink or smoke when using this product. Remove and wash contaminated clothing and gloves, including the inside, before re-use. Wash hands before breaks and after work.

7.2. Conditions for safe storage, including any incompatibilities

Keep in a dry, cool and well-ventilated place. Keep container tightly closed.

Technical Rules for Hazardous Substances (TRGS) 510 Class 13 Storage Class (LGK) (Germany)

7.3. Specific end use(s)

Use in laboratories

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1. Control parameters

Exposure limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies

Biological limit values This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific regulatory bodies

Derived No Effect Level (DNEL) / Derived Minimum Effect Level (DMEL) No information available

Predicted No Effect Concentration (PNEC) No information available.

8.2. Exposure controls

Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to

SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________ control hazardous materials at source

Personal protective equipment Eye Protection Goggles (European standard - EN 166)

Hand Protection Protective gloves

Glove material Breakthrough time Glove thickness EU standard Glove comments Natural rubber See manufacturers - EN 374 (minimum requirement) Nitrile rubber recommendations Neoprene PVC Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Inspect gloves before use. Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. (Refer to manufacturer/supplier for information) Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g. sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion. Remove gloves with care avoiding skin contamination.

Respiratory Protection When workers are facing concentrations above the exposure limit they must use appropriate certified respirators. To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly

Large scale/emergency use Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced Recommended Filter type: Particulates filter conforming to EN 143

Small scale/Laboratory use Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Recommended half mask:- Particle filtering: EN149:2001 When RPE is used a face piece Fit Test should be conducted

Environmental exposure controls No information available.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Physical State Solid

Appearance White Odor No information available Odor Threshold No data available Melting Point/Range No data available Softening Point No data available Boiling Point/Range No information available Flammability (liquid) Not applicable Solid Flammability (solid,gas) No information available Explosion Limits No data available

Flash Point No information available Method - No information available Autoignition Temperature No data available Decomposition Temperature No data available pH No information available Viscosity Not applicable Solid Water Solubility Soluble Solubility in other solvents No information available Partition Coefficient (n-octanol/water) Vapor Pressure No data available Density / Specific Gravity 3.010

SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________ Bulk Density No data available Vapor Density Not applicable Solid Particle characteristics No data available

9.2. Other information

Molecular Formula Gd2 O12 S3 . 8 H2 O Molecular Weight 746.81 Evaporation Rate Not applicable - Solid

SECTION 10: STABILITY AND REACTIVITY

10.1. Reactivity None known, based on information available

10.2. Chemical stability Stable under normal conditions. Hygroscopic.

10.3. Possibility of hazardous reactions

Hazardous Polymerization Hazardous polymerization does not occur. Hazardous Reactions No information available.

10.4. Conditions to avoid Incompatible products. Exposure to moist air or water.

10.5. Incompatible materials Strong oxidizing agents.

10.6. Hazardous decomposition products

Sulfur oxides.

SECTION 11: TOXICOLOGICAL INFORMATION

11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008

Product Information No acute toxicity information is available for this product

(a) acute toxicity; Oral No data available Dermal No data available Inhalation No data available

(b) skin corrosion/irritation; Category 2

(c) serious eye damage/irritation; Category 2

(d) respiratory or skin sensitization; Respiratory No data available Skin No data available

(e) germ cell mutagenicity; No data available

(f) carcinogenicity; No data available

There are no known carcinogenic chemicals in this product

SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________

(g) reproductive toxicity; No data available

(h) STOT-single exposure; Category 3

Results / Target organs Respiratory system.

(i) STOT-repeated exposure; No data available

Target Organs No information available.

(j) aspiration hazard; Not applicable Solid

Other Adverse Effects The toxicological properties have not been fully investigated.

Symptoms / effects,both acute and No information available. delayed

11.2. Information on other hazards

Endocrine Disrupting Properties Assess endocrine disrupting properties for human health. This product does not contain any known or suspected endocrine disruptors.

SECTION 12: ECOLOGICAL INFORMATION

12.1. Toxicity Ecotoxicity effects Do not empty into drains.

12.2. Persistence and degradability Persistence Soluble in water, Persistence is unlikely, based on information available. Degradability Not relevant for inorganic substances.

12.3. Bioaccumulative potential Bioaccumulation is unlikely

12.4. Mobility in soil The product is water soluble, and may spread in water systems Will likely be mobile in the environment due to its water solubility. Highly mobile in soils

12.5. Results of PBT and vPvB No data available for assessment. assessment

12.6. Endocrine disrupting properties Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors

12.7. Other adverse effects

Persistent Organic Pollutant This product does not contain any known or suspected substance Ozone Depletion Potential This product does not contain any known or suspected substance

SECTION 13: DISPOSAL CONSIDERATIONS

SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________

13.1. Waste treatment methods

Waste from Residues/Unused Waste is classified as hazardous. Dispose of in accordance with the European Directives Products on waste and hazardous waste. Dispose of in accordance with local regulations.

Contaminated Packaging Dispose of this container to hazardous or special waste collection point.

European Waste Catalogue (EWC) According to the European Waste Catalog, Waste Codes are not product specific, but application specific.

Other Information Waste codes should be assigned by the user based on the application for which the product was used. Do not empty into drains.

SECTION 14: TRANSPORT INFORMATION

IMDG/IMO Not regulated

14.1. UN number 14.2. UN proper shipping name

14.3. Transport hazard class(es)

14.4. Packing group

ADR Not regulated

14.1. UN number 14.2. UN proper shipping name

14.3. Transport hazard class(es)

14.4. Packing group

IATA Not regulated

14.1. UN number 14.2. UN proper shipping name

14.3. Transport hazard class(es)

14.4. Packing group

14.5. Environmental hazards No hazards identified

14.6. Special precautions for user No special precautions required.

14.7. Maritime transport in bulk Not applicable, packaged goods according to IMO instruments

SECTION 15: REGULATORY INFORMATION

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

International Inventories Europe (EINECS/ELINCS/NLP), China (IECSC), Taiwan (TCSI), Korea (KECL), Japan (ENCS), Japan (ISHL), Canada (DSL/NDSL), Australia (AICS), New Zealand (NZIoC), Philippines (PICCS). US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)

Component CAS No EINECS ELINCS NLP IECSC TCSI KECL ENCS ISHL Gadolinium(III) sulfate octahydrate 13450-87-8 - - - - X - - -

Component CAS No TSCA TSCA Inventory DSL NDSL AICS NZIoC PICCS notification -

SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________ Active-Inactive Gadolinium(III) sulfate octahydrate 13450-87-8 - - - - - - -

Legend: X - Listed '-' - Not Listed KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

Authorisation/Restrictions according to EU REACH Not applicable

Component CAS No REACH (1907/2006) - REACH (1907/2006) - REACH Regulation (EC Annex XIV - Substances Annex XVII - Restrictions 1907/2006) article 59 - Subject to Authorization on Certain Dangerous Candidate List of Substances Substances of Very High Concern (SVHC) Gadolinium(III) sulfate octahydrate 13450-87-8 - - -

Seveso III Directive (2012/18/EC)

Component CAS No Seveso III Directive (2012/18/EC) - Seveso III Directive (2012/18/EC) - Qualifying Quantities for Major Accident Qualifying Quantities for Safety Report Notification Requirements Gadolinium(III) sulfate 13450-87-8 Not applicable Not applicable octahydrate

Regulation (EC) No 649/2012 of the European Parliament and of the Council of 4 July 2012 concerning the export and import of dangerous chemicals Not applicable

Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)? Not applicable

Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at work .

National Regulations

UK - Take note of Control of Substances Hazardous to Health Regulations (COSHH) 2002 and 2005 Amendment

WGK Classification Water endangering class = 3 (self classification)

15.2. Chemical safety assessment

A Chemical Safety Assessment/Report (CSA/CSR) has not been conducted

SECTION 16: OTHER INFORMATION

Full text of H-Statements referred to under sections 2 and 3 H315 - Causes skin irritation H319 - Causes serious eye irritation H335 - May cause respiratory irritation

Legend

SAFETY DATA SHEET Gadolinium (III) sulfate Revision Date 02-Feb-2024 ______________________________________________________________________________________________ CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b) Inventory EINECS/ELINCS - European Inventory of Existing Commercial Chemical DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances/EU List of Notified Chemical Substances Substances List PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals

WEL - Workplace Exposure Limit TWA - Time Weighted Average ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer DNEL - Derived No Effect Level Predicted No Effect Concentration (PNEC) RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50% LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50% NOEC - No Observed Effect Concentration POW - Partition coefficient Octanol:Water PBT - Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative

ADR - European Agreement Concerning the International Carriage of ICAO/IATA - International Civil Aviation Organization/International Air Dangerous Goods by Road Transport Association IMO/IMDG - International Maritime Organization/International Maritime MARPOL - International Convention for the Prevention of Pollution from Dangerous Goods Code Ships OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate BCF - Bioconcentration factor VOC - (Volatile Organic Compound) Key literature references and sources for data https://echa.europa.eu/information-on-chemicals Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS

Training Advice Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene. Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards. First aid for chemical exposure, including the use of eye wash and safety showers.

Prepared By Health, Safety and Environmental Department Revision Date 02-Feb-2024 Revision Summary New emergency telephone response service provider.

This safety data sheet complies with Regulation UK SI 2019/758 and UK SI 2020/1577 as amended. .

.

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

End of Safety Data Sheet