LUIS-1 Lutetium Isotopic Certified Reference Material (calibration solution) LUIS-1 CRM SDS

LUIS Safety Data Sheet according to the Hazard Communication Standard (CFR29 1910.1200) HazCom 2012 and the Hazardous Products Regulations (HPR) WHMIS 2015 Date of issue: 2019-08-26 Revision date: 2019-08-26 Version: 1.0

SECTION 1: Identification

1.1. Product identifier

Product form : Mixture Product name : LUIS Product code : Not available

1.2. Relevant identified uses of the substance or mixture and uses advised against Use of the substance/mixture : Lutetium isotopic CRM, for laboratory use only

1.3. Details of the supplier of the safety data sheet National Research Council Canada 1200 Montreal Road, Building M12 Ottawa, K1A 0R6 - Canada T 613-993-2359

1.4. Emergency telephone number Emergency number : CANUTEC 1-613-996-6666

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture

GHS classification Skin Irritation. 2 Eye Irritation. 2A

2.2. Label elements GHS labelling Hazard pictograms (GHS) :

GHS07 Signal word (GHS) : Warning Hazard statements (GHS) : Causes skin irritation. Causes serious eye irritation. Precautionary statements (GHS) : Wash hands, forearms and face thoroughly after handling. Wear protective gloves/protective clothing/eye protection/face protection. If on skin: Wash with plenty of water. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash it before reuse. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.

2.3. Other hazards

No additional information available

2.4. Unknown acute toxicity (GHS) Not applicable

SECTION 3: Composition/information on ingredients

3.1. Substances Not applicable

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LUIS Safety Data Sheet according to the Hazard Communication Standard (CFR29 1910.1200) HazCom 2012 and the Hazardous Products Regulations (HPR) WHMIS 2015

3.2. Mixtures

Name Product identifier % (by weight) Nitric acid (CAS-No.) 7697-37-2 2.0 Lutetium oxide (Lu2O3) (CAS-No.) 12032-20-1 0.1

SECTION 4: First aid measures

4.1. Description of first aid measures First-aid measures after inhalation : If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. First-aid measures after skin contact : IF ON SKIN: Wash with plenty of water. Take off contaminated clothing and wash it before reuse. If skin irritation occurs: Get medical advice/attention. First-aid measures after eye contact : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. First-aid measures after ingestion : If swallowed, do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical advice/attention if you feel unwell.

4.2. Most important symptoms and effects, both acute and delayed Symptoms/effects after inhalation : May cause irritation to the respiratory tract. Symptoms/effects after skin contact : Causes skin irritation. Symptoms may include redness, drying, defatting and cracking of the skin. Symptoms/effects after eye contact : Causes serious eye irritation. Symptoms may include discomfort or pain, excess blinking and tear production, with marked redness and swelling of the conjunctiva. Symptoms/effects after ingestion : May be harmful if swallowed. May cause stomach distress, nausea or vomiting.

4.3. Indication of any immediate medical attention and special treatment needed Symptoms may be delayed. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

SECTION 5: Firefighting measures

5.1. Extinguishing media Suitable extinguishing media : Treat for surrounding material. Unsuitable extinguishing media : None known.

5.2. Special hazards arising from the substance or mixture Fire hazard : Products of combustion may include, and are not limited to: oxides of carbon. Oxides of nitrogen.

5.3. Advice for firefighters Protection during firefighting : Keep upwind of fire. Wear full fire fighting turn-out gear (full Bunker gear) and respiratory protection (SCBA).

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures General measures : Use personal protection recommended in Section 8. Isolate the hazard area and deny entry to unnecessary and unprotected personnel.

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LUIS Safety Data Sheet according to the Hazard Communication Standard (CFR29 1910.1200) HazCom 2012 and the Hazardous Products Regulations (HPR) WHMIS 2015

6.2. Methods and material for containment and cleaning up For containment : Absorb and/or contain spill with inert material (sand, vermiculite or other appropriate material), then place in suitable container. Do not flush into surface water or sewer system. Wear recommended personal protective equipment. Methods for cleaning up : Scoop up material and place in a disposal container. Provide ventilation.

6.3. Reference to other sections For further information refer to section 8: "Exposure controls/personal protection".

SECTION 7: Handling and storage

7.1. Precautions for safe handling Precautions for safe handling : Avoid contact with skin and eyes. Avoid breathing dust/fume/gas/mist/vapours/spray. Do not swallow. Handle and open container with care. When using do not eat, drink or smoke. Hygiene measures : Launder contaminated clothing before reuse. Wash hands, forearms and face thoroughly after handling.

7.2. Conditions for safe storage, including any incompatibilities Storage conditions : Keep out of the reach of children. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Keep away from (strong) bases

SECTION 8: Exposure controls/personal protection

8.1. Control parameters

Nitric acid (7697-37-2) ACGIH ACGIH TWA (ppm) 2 ppm

ACGIH ACGIH STEL (ppm) 4 ppm

OSHA OSHA PEL (TWA) (mg/m³) 5 mg/m³

OSHA OSHA PEL (TWA) (ppm) 2 ppm

IDLH US IDLH (ppm) 25 ppm

NIOSH NIOSH REL (TWA) (mg/m³) 5 mg/m³

NIOSH NIOSH REL (TWA) (ppm) 2 ppm

NIOSH NIOSH REL (STEL) (mg/m³) 10 mg/m³

NIOSH NIOSH REL (STEL) (ppm) 4 ppm

Lutetium oxide (Lu2O3) (12032-20-1) ACGIH ACGIH TWA (ppm) 20 ppm

OSHA OSHA PEL (TWA) (mg/m³) 70 mg/m³

OSHA OSHA PEL (TWA) (ppm) 40 ppm

IDLH US IDLH (ppm) 137 ppm

8.2. Exposure controls

Appropriate engineering controls : Use ventilation adequate to keep exposures (airborne levels of dust, fume, vapor, etc.) below recommended exposure limits. Hand protection : Wear suitable gloves resistant to chemical penetration. Eye protection : Wear eye/face protection. Skin and body protection : Wear suitable protective clothing.

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LUIS Safety Data Sheet according to the Hazard Communication Standard (CFR29 1910.1200) HazCom 2012 and the Hazardous Products Regulations (HPR) WHMIS 2015

Respiratory protection : In case of insufficient ventilation, wear suitable respiratory equipment. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator. Environmental exposure controls : Maintain levels below Community environmental protection thresholds. Other information : Do not eat, smoke or drink where material is handled, processed or stored. Wash hands carefully before eating or smoking. Handle according to established industrial hygiene and safety practices.

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties Physical state : Liquid Appearance : Colourless liquid. Colour : Colourless Odour : No data available Odour threshold : No data available pH : No data available Melting point : No data available Freezing point : No data available Boiling point : No data available Flash point : No data available Relative evaporation rate : No data available (butylacetate=1) Flammability (solid, gas) : Not Flammable Vapour pressure : No data available Relative vapour density at 20 °C : No data available Relative density : No data available Solubility : No data available Partition coefficient n-octanol/water : No data available Auto-ignition temperature : No data available Decomposition temperature : No data available Viscosity, kinematic : No data available Viscosity, dynamic : No data available Explosive limits : No data available Explosive properties : No data available Oxidising properties : No data available

9.2. Other information

No additional information available

SECTION 10: Stability and reactivity

10.1. Reactivity No dangerous reactions known under normal conditions of use.

10.2. Chemical stability Stable under normal conditions.

10.3. Possibility of hazardous reactions No dangerous reactions known under normal conditions of use.

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LUIS Safety Data Sheet according to the Hazard Communication Standard (CFR29 1910.1200) HazCom 2012 and the Hazardous Products Regulations (HPR) WHMIS 2015

10.4. Conditions to avoid Heat. Incompatible materials

10.5. Incompatible materials Bases. Reducing agents. Metallic powders. Organic materials.

10.6. Hazardous decomposition products

May include, and are not limited to: oxides of carbon. Oxides of nitrogen.

SECTION 11: Toxicological information

11.1. Information on toxicological effects

Acute toxicity (oral) : Not classified. Acute toxicity (dermal) : Not classified. Acute toxicity (inhalation) : Not classified.

Nitric acid (7697-37-2) LC50 inhalation rat 1610.68 mg/m³ LC50 inhalation rat 2500 ppm/1h

Skin corrosion/irritation : Causes skin irritation. Serious eye damage/irritation : Causes serious eye irritation. Respiratory or skin sensitisation : Based on available data, the classification criteria are not met. Germ cell mutagenicity : Based on available data, the classification criteria are not met. Carcinogenicity : Based on available data, the classification criteria are not met. Reproductive toxicity : Based on available data, the classification criteria are not met. STOT-single exposure : Based on available data, the classification criteria are not met. STOT-repeated exposure : Based on available data, the classification criteria are not met. Aspiration hazard : Based on available data, the classification criteria are not met. Symptoms/effects after inhalation : May cause irritation to the respiratory tract. Symptoms/effects after skin contact : Causes skin irritation. Symptoms may include redness, drying, defatting and cracking of the skin. Symptoms/effects after eye contact : Causes serious eye irritation. Symptoms may include discomfort or pain, excess blinking and tear production, with marked redness and swelling of the conjunctiva. Symptoms/effects after ingestion : May be harmful if swallowed. May cause stomach distress, nausea or vomiting. Other information : Likely routes of exposure: ingestion, inhalation, skin and eye.

SECTION 12: Ecological information

12.1. Toxicity Ecology - general : May cause long-term adverse effects in the aquatic environment.

12.2. Persistence and degradability LUIS Persistence and degradability Not established. 12.3. Bioaccumulative potential LUIS Bioaccumulative potential Not established.

Nitric acid (7697-37-2) Partition coefficient n-octanol/water -2.3 (at 25 °C)

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LUIS Safety Data Sheet according to the Hazard Communication Standard (CFR29 1910.1200) HazCom 2012 and the Hazardous Products Regulations (HPR) WHMIS 2015

12.4. Mobility in soil No additional information available

12.5. Other adverse effects

No additional information available

SECTION 13: Disposal considerations

13.1. Waste treatment methods Product/Packaging disposal : This material must be disposed of in accordance with all local, state, recommendations provincial, and federal regulations. The generation of waste should be avoided or minimized wherever possible.

SECTION 14: Transport information

Department of Transportation (DOT) and Transportation of Dangerous Goods (TDG) In accordance with DOT/TDG Not regulated for transport

Additional information Other information : No supplementary information available. Special transport precautions : Do not handle until all safety precautions have been read and understood.

SECTION 15: Regulatory information

15.1. Federal regulations

All components of this product are listed, or excluded from listing, on the United States Environmental Protection Agency Toxic Substances Control Act (TSCA) inventory.

All components of this product are listed, or excluded from listing, on the Canadian DSL (Domestic Substances List) and NDSL (Non-Domestic Substances List) inventories.

Nitric acid (7697-37-2) Listed on the United States SARA Section 302 Subject to reporting requirements of United States SARA Section 313 CERCLA RQ 1000 lb SARA Section 302 Threshold 1000 lb Planning Quantity (TPQ) SARA Section 313 - Emission 1.0 % Reporting

15.2 US State regulations No additional information available

SECTION 16: Other information

Date of issue : 2019-08-26 Revision date : 2019-08-26 Other information : None. Version # : 1.0 Prepared by : Nexreg Compliance Inc.

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LUIS Safety Data Sheet according to the Hazard Communication Standard (CFR29 1910.1200) HazCom 2012 and the Hazardous Products Regulations (HPR) WHMIS 2015

DISCLAIMER: The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text.

This material is for research and experimental applications only. It is not intended for food, drug, household, agricultural, or cosmetic use. Its use must be supervised by technically qualified individuals with experience in the handling of potentially hazardous chemicals. Apart from the solvent in this product (if applicable), the hazardous components present in the solution are at such low concentrations that exact determination of degree of hazard is not warranted and would be misleading. We shall not be held liable for any damage resulting from handling or from contact with the above product.

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