Lutetium-175 SDS

Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

Section 1: Identification of the Substance/Mixture and of the Company/Undertaking

Product Identifier: Identification as on the label/Trade name: Lutetium (III) Oxide, Enriched Lutetium Oxide. Molecular weight: 397.94 Chemical formula: Lu2O3 Synonyms: Lutetia, Lutetium trioxide, Cassiopeium oxide.

Details of the supplier of the Safety Data Sheet: Neonest AB Storgatan 70C, Solna SE-17152 Sweden

Contact details: +46-76-219-9731

24-hour Emergency Contact: Swedish Poisons Centre Phone: 112 - Ask for Poisons Information, 112 – begär Giftinformation.

Other International Contacts: CHEMTREC 24-hour: +1-703-741-5500 (US + Worldwide) NHS: 111 (UK) Charite: +49 30 450 531 000 (Netherlands) INTCF: +34 917689800 (Spain) CapTv: +33 1 40 05 48 48 (France)

Section 2: Hazards Identification

Classification of the substances or mixture: The mixture is classified according to: Regulation EC 1272/2008 [EU-GHS/CLP]

Hazard classes/Hazard categories: Hazard statement: Not classified as hazardous. None required.

Label elements: Hazard pictograms: Not required. Signal Words: Not required. Hazard Statements: Not required. Precautionary Statements: None. Other hazards: None known.

Safety Data Sheet (SDS) for Lutetium (III) Oxide, Enriched Lutetium Oxide https://www.buyisotope.com Page 1/9

Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

Section 3: Composition/Information on Ingredients

Substance/Mixture: Substance. Ingredients:

CAS-No. Molecular Concentration Classification Substance name (IUPAC/EC) EC-No. weight % by weight EC1272/2008 12032-20-1 Lutetium dioxide 397.94 >99% Not Classified. 234-764-3

For explanation of abbreviations see Section 16.

Section 4: First-Aid Measures

Description of first aid measures: In case of inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. In case of skin contact: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Seek medical attention if symptoms persist. In case of eye contact: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical attention. In case of ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, patient should rinse mouth and drink 2-4 cups of milk or water.

Most important symptoms and effects, both acute and delayed: Inhalation: Causes respiratory tract irritation. Can produce delayed pulmonary edema. The toxicological properties of this substance have not been fully investigated. Eyes: Causes eye irritation. May cause chemical conjunctivitis. Skin contact: Causes skin irritation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhoea. The toxicological properties of this substance have not been fully investigated. Indication of any immediate medical attention and special treatment needed: Treat symptomatically. Show this safety data sheet to a physician or emergency room.

Section 5: Fire-Fighting Measures

Extinguisher media: Suitable extinguisher media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Unsuitable extinguishing media: None known. Special hazards arising from the mixture: None known. Advice for fire-fighters: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.

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Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

Further information: Standard procedure for chemical fires. Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Section 6: Accidental Release Measures

Personal precautions, protective equipment and emergency procedures: Personal precautions: Use proper personal protective equipment as indicated in Section 8. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent product from entering drains. Prevent further leakage or spillage if safe to do so. Local authorities should be advised if significant spillages cannot be contained.

Methods for containment and cleaning up: Methods for cleaning up: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Provide ventilation.

Reference to other sections: Treat recovered material as described in the section "Disposal considerations".

Section 7: Handling and Storage

Precautions for safe handling: Advice on safe handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Keep from contact with moist air and steam. Hygiene measures: Do not eat, drink or smoke when using this product.

Conditions for safe storage, including incompatibilities: Requirements for storage areas and containers: Store in a tightly closed container. Store in a cool, dry, well- ventilated area away from incompatible substances. Store protected from moisture.

Section 8: Exposure Controls/Personal Protection

Control parameters: Occupational exposure limits: Contains no substances with occupational exposure limit values

Exposure controls: Appropriate engineering controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.

Individual protection measures, such as personal protective equipment: Eye/face protection: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Hand protection: Use chemical resistant gloves. Examples of preferred glove barrier materials include: Butyl rubber, Neoprene, Nitrile/butadiene rubber, Polyethylene, Ethyl vinyl alcohol laminate, polyvinyl alcohol, Polyvinyl chloride. Body protection: Wear appropriate protective clothing to prevent skin exposure.

Safety Data Sheet (SDS) for Lutetium (III) Oxide, Enriched Lutetium Oxide https://www.buyisotope.com Page 3/9

Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

Respiratory protection: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Section 9: Physical and Chemical Properties

Information on basic physical and chemical properties Appearance (form): Solid (crystalline powder). Colour: White. Odour: No data available. Odour threshold: No data available. Molecular Weight: 397.94 pH (concentration): No data available. Melting point/range (°C): 2487 °C Boiling point/range (°C): No data available. Freezing point (°C): No data available. Flash point (°C): No data available. Evaporation rate: No data available. Flammability (solid, gas): No data available. Ignition temperature (°C): No data available. Upper/lower flammability/explosive limits: No data available. Vapour pressure (20 °C): No data available Vapour density: No data available. Relative density (25 °C): 9.4200 g/cm3 Water solubility (g/L) at 20 °C: No data available. n-Octanol/Water partition coefficient: No data available. Auto-ignition temperature: No data available. Decomposition temperature: No data available. Viscosity, dynamic (mPa s): No data available. Explosive properties: The substance or mixture is not classified as explosive. Oxidising properties: The substance or mixture is not classified as oxidizing.

Section 10: Stability and Reactivity

Reactivity: No dangerous reaction known under conditions of normal use. Chemical stability: Stable under normal conditions. Possibility of hazardous reactions: No dangerous reaction known under conditions of normal use. Conditions to avoid: Excess heat, strong oxidants. Incompatible materials: Strong oxidizing agents, carbon dioxide, moisture. Hazardous decomposition products: Irritating and toxic fumes and gases.

Section 11: Toxicological Information

Information on toxicological effects: Not classified based on available information. Classification according to GHS (1272/2008/EG, CLP)

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Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

Skin corrosion/irritation: Not classified based on available information. Serious eye damage/eye irritation: Not classified based on available information. Respiratory or skin sensitisation: Not classified based on available information. Germ cell mutagenicity: Not classified based on available information. Carcinogenicity: EPA: No classification data on carcinogenic properties of this material is available. IARC: No classification data on carcinogenic properties of this material is available. NTP: No classification data on carcinogenic properties of this material is available. OSHA: No classification data on carcinogenic properties of this material is available. ACGIH: No classification data on carcinogenic properties of this material is available. Reproductive toxicity: Not classified based on available information. Specific target organ toxicity – single exposure (STOT): Not classified based on available information. Specific target organ toxicity (STOT) – repeated exposure: Not classified based on available information. Aspiration toxicity: Not classified based on available information.

Section 12: Ecological Information

Toxicity: No data available. Persistence and degradability: No data available. Bioaccumulative potential: No data available. Mobility in soil: No data available. Results of PBT& vPvB assessment: Not relevant. Other adverse effects: No data available.

Section 13: Disposal Considerations

Waste treatment methods: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Additionally, waste generators must consult local and national hazardous waste regulations to ensure complete and accurate classification.

Section 14: Transport Information

UN number: Not regulated as a dangerous good. UN proper shipping name: Not regulated as a dangerous good. Transport hazard class(es): Not regulated as a dangerous good. Packing group: Not regulated as a dangerous good. Environmental hazards: Not regulated as a dangerous good. Special precautions for user: Not dangerous goods in the meaning of ADR/RID, ADN, IMDG-Code, ICAO/IATA-DGR.

Safety Data Sheet (SDS) for Lutetium (III) Oxide, Enriched Lutetium Oxide https://www.buyisotope.com Page 5/9

Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

Transport in bulk according to Annex II of Marpol and the IBC Code: Not applicable.

Section 15: Regulatory Information

EU regulations: Regulation (EC) No. 1005/2009 on substances that deplete the ozone layer, Annex I and II, as amended Not listed. Regulation (EC) No. 850/2004 on persistent organic pollutants, Annex I Not listed. Regulation (EU) No. 649/2012 concerning the export and import of dangerous chemicals, Annex I, Part 1 as amended Not listed. Regulation (EU) No. 649/2012 concerning the export and import of dangerous chemicals, Annex I, Part 2 as amended Not listed. Regulation (EU) No. 649/2012 concerning the export and import of dangerous chemicals, Annex I, Part 3 as amended Not listed. Regulation (EU) No. 649/2012 concerning the export and import of dangerous chemicals, Annex V as amended Not listed. Regulation (EC) No. 166/2006 Annex II Pollutant Release and Transfer Registry Not listed. Regulation (EC) No. 1907/2006, REACH Article 59(10) Candidate List as currently published by ECHA Not listed.

Authorisations: Regulation (EC) No. 1907/2006, REACH Annex XIV Substances subject to authorization, as amended Not listed.

Restrictions on use: Regulation (EC) No. 1907/2006 Annex XVII Substances subject to restriction on marketing and use Not regulated. Regulation (EC) No. 1907/2006, REACH Annex XVII Substances subject to restriction on marketing and use as amended Not listed. Directive 2004/37/EC on the protection of workers from the risks related to exposure to carcinogens and mutagens at work Not regulated. Directive 92/85/EEC: on the safety and health of pregnant workers and workers who have recently given birth or are breastfeeding. Not regulated.

Other EU regulations: Directive 2012/18/EU on major accident hazards involving dangerous substances Not listed. Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at work.

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Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

Always applicable. Directive 94/33/EC on the protection of young people at work Not listed.

Other regulations: The product is classified and labelled in accordance with EC directives or respective national laws. This Safety Data Sheet complies with the requirements of Regulation (EC) No 1907/2006, as amended. US Federal TSCA: CAS# 12032-20-1 is listed on the TSCA inventory. Health & Safety Reporting List: None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules: None of the chemicals in this product are under a Chemical Test Rule.

Section 12b: None of the chemicals are listed under TSCA Section 12b.

TSCA Significant New Use Rule: None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and Corresponding RQs: None of the chemicals in this material have an RQ. SARA Section 302: None of the chemicals in this product have a TPQ. SARA Section 313: No chemicals are reportable under Section 313. SARA 311/312 Acute Health Hazard. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. US States: CAS# 12032-20-1 is not present on state lists from CA, PA, MN, MA, FL or NJ. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives: Hazard Symbols: Not available Risk Phrases: Not available Safety Phrases: S 24/25 Avoid contact with skin and eyes WGK (Water Danger/Protection): CAS# 12032-20-1: No information available. Canada - DSL/NDSL: CAS# 12032-20-1 is listed on Canada's DSL List. Canada – WHMIS: This product has a WHMIS classification of D2B. National regulations: Follow national regulation for work with chemical agents. Chemical safety assessment: No Chemical Safety Assessment has been carried out.

Section 16: Other Information

List of abbreviations: ACGIH American Conference of Governmental Industrial Hygienists ADR European Agreement Concerning the International Carriage of Dangerous Goods by Road ALARA As Low As Is Reasonably Achievable AMU Atomic Mass Unit ANSI American National Standards Institute BLS Basic Life Support CAM Continuous Air Monitor CAS Chemical Abstracts Service (division of the American Chemical Society)

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Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

CEN European Committee for Standardization CERCLA Comprehensive Environmental Response Compensation and Liability Act CLP Classification, Labelling and Packaging (European Union) CPR Controlled Products Regulations (Canada) CWA Clean Water Act (USA) DAC Derived Air Concentration (USA) DOE United States Department of Energy (USA) DOT United States Department of Transportation (USA) DSL Domestic Substances List (Canada) EC50 Half Maximal Effective Concentration EINECS European Inventory of Existing Commercial Chemical Substances EHS Environmentally Hazardous Substance ELINCS European List of Notified Chemical Substances EMS Emergency Response Procedures for Ships Carrying Dangerous Goods EPA Environmental Protection Agency (USA) EPCRA Emergency Planning and Community Right-To-Know Act (EPCRA) of 1986 GHS Globally Harmonized System HMIS Hazardous Materials Identification System (USA) IARC International Agency for Research on Cancer IATA International Air Transport Association IBC Intermediate Bulk Containers ICAO International Civil Aviation Organization IDLH Immediately Dangerous to Life or Health IMDG International Maritime Code for Dangerous Goods LC50 Lethal concentration, 50 percent LD50 Lethal dose, 50 percent LDLO Lethal Dose Low LOEC Lowest-Observed-Effective Concentration MARPOL International Convention for the Prevention of Pollution from Ships MSHA Mine Safety and Health Administration (USA) NCRP National Council on Radiation Protection & Measurements (USA) NDSL Non-Domestic Substances List (Canada) NFPA National Fire Protection Association (USA) NIOSH National Institute for Occupational Safety and Health (USA) NOEC No Observed Effect Concentration N.O.S. Not Otherwise Specified NRC Nuclear Regulatory Commission (USA) NTP National Toxicology Program (USA) OSHA Occupational Safety and Health Administration (USA) PBT Persistent Bioaccumulative and Toxic Chemical PEL Permissible Exposure Limit PIH Poisonous by Inhalation Hazard RCRA Resource Conservation and Recovery Act (USA) RCT Radiation Control Technician REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (Europe) RID Regulations Concerning the International Transport of Dangerous Goods by Rail RTECS Registry of Toxic Effects of Chemical Substances

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Safety Data Sheet for Lutetium Oxide, Enriched Lutetium Oxide According to ISO 11014:2010

First Print Date: 5-Mar-2015 Revision Date: 15-Aug-2019 Version: 1.1.1.

SARA Superfund Amendments and Reauthorization Act (USA) TDG Transportation of Dangerous Goods (Canada) TIH Toxic by Inhalation Hazard TLV Threshold Limit Value TPQ Threshold Planning Quantity TSCA Toxic Substances Control Act TWA Time Weighted Average UN United Nations (Number) VOC Volatile Organic Compound vPvB Very Persistent Very Bioaccumulative Chemical WGK Wassergefährdungsklassen (Germany: Water Hazard Classes) WHMIS Workplace Hazardous Materials Information System References: Not available. Full text of any H-statements not written out in full under Sections 2 to 15: None. Revision information: None. Training information: Follow training instructions when handling this material. Further Information: The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.

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